JuveLook 1x50mg

• Poly-D,L-lactic acid (PDLLA): 42.5 mg per vial, in the form of microspheres. Unlike PLLA, PDLLA is an amorphous polymer with more homogeneous degradation and, according to the manufacturer, a lower risk of nodule formation.
• Non-cross-linked hyaluronic acid: 7.5 mg per vial. It does not act as a filler: it provides immediate hydration and serves as a vehicle for uniform dispersion of the microspheres in the tissue.
• Lyophilised presentation: the vial is reconstituted before application.
• Mechanism: the PDLLA microspheres induce a tissue remodelling response with progressive collagen synthesis; the polymer is biodegraded by hydrolysis to lactic acid and eliminated metabolically.

The manufacturer does not publish a single verifiable value for the size of the microspheres; the figures circulating in distribution documentation are inconsistent, and therefore no range is stated here.

Injectable biostimulator indicated for improving skin quality and correcting fine lines in adult patients.

• Fine lines: crow's feet, forehead wrinkles, perioral wrinkles
• Enlarged pores and uneven texture
• Mild skin laxity
• Atrophic acne scars
• Neck, décolleté and dorsum of the hands

It must not be injected into the lips or the periorbital fat pads. Periocular treatment requires specific experience and a controlled plane.

The reconstitution protocol is the critical point of the product. The procedure stated in the instructions for use accompanying the batch must be followed; the parameters of volume, mixing method and standing time are not indicative but product specifications.

• Reconstitution volume: 6 ml of bacteriostatic saline per vial, according to the optimised reconstitution protocol issued by the product's official European distribution.
• Mixing: vigorous manual lateral shaking for approximately 2 minutes, or vortex mixing for about 5 minutes, until a homogeneous suspension is obtained. Do not shake harshly for a prolonged period: this may damage the microspheres.
• Standing time: consult the instructions for use of the batch. The indications published by different distributors differ from one another, and therefore no figure is reproduced here.
• Injection plane: superficial to mid dermis.
• Technique: serial microinjections (micropapule/mesotherapy) for fine lines, pores and texture; linear retrograde injection or cannula for larger surface areas.
• Massage afterwards: massage the treated area firmly after the session to even out the distribution of the product.
• Number of sessions: the manufacturer recommends 3 sessions at intervals of approximately one month.
• Onset of result: progressive. Collagen remodelling develops over several weeks after each session.
• The reconstituted product is used in the same session, unless otherwise stated in the instructions for use.

• The pack includes: 1 lyophilised vial of 50 mg and instructions for use. The solvent is not included.
• Storage: the lyophilised vial is stored in its original packaging, protected from light and moisture, under the conditions stated on the packaging.
• Do not use after the expiry date stated on the packaging.
• Sterile single-use product. Do not reuse or re-sterilise.
• Prepare the reconstitution under aseptic conditions.

Contraindications: known hypersensitivity to polylactic acid or to hyaluronic acid; active skin infection or inflammation in the treatment area; pregnancy and breastfeeding; active autoimmune disease; tendency to hypertrophic or keloid scarring; patients under 18 years of age.

Warnings specific to biostimulators: injection that is too superficial, uneven distribution or insufficient massage after the session are associated with the formation of nodules and papules. Observe the stated injection plane and technique. Do not overcorrect: the effect is progressive and is assessed between sessions.

Never inject intravascularly. Do not apply to the lips or the periorbital fat pads. Always consult the instructions for use enclosed in the packaging before application.